Yes, all kinds of medication and medication interactions can affect sexual desire and performance - far more than most people are commonly aware of. Many mood stabilizers such as antidepressants or anti-anxiety medications such as Zoloft, Prozac, and Paxil delay or prevent orgasm. Medications to control heart rates, chronic diseases and hosts of other medications can also impact sexual performance. If you have any questions, read the pamphlet that comes with the medication and talk with your medical professional. Also, be sure to tell your MD all prescriptions and over-the-counter or homeopathic medications you are taking as the interactions may negatively affect sexual desire and/or performance. Sometimes a lower dose may eliminate the difficulty or a change in medication may be required. But this is not something to fiddle around with yourself. Talk to your professional and don't be shy about it.